diagnosis

=DIAGNOSIS=

a) Biomarkers
1) CSF (abeta, total tau, and tau hyperphosphorylated at threonine residues 181 and 231)









2) Plasma (complement factor H, alpha-2-macroglobulin, clusterin)





b) Imaging
1) Structural MRI (medial temporal lobe atrophy, volumetric analysis, hippocampus mapping, cortical thickness)



2) Functional MRI



3) PET (fluorodeoxyglucose, 11C-labelled Pittsburg compound/PIB, 18F-labelled Abeta ligand)





4) SPECT (99m Tc -HMPAO or 133Xe)

c) Correspondence between imaging and biomarkers